Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos.
نویسندگان
چکیده
منابع مشابه
O-35: Over-Expression of XRCC1 As Potential Biomarker for Poor Prognosis in Human Preimplantation Embryos: Selection by Study of 84 Genes Involved in DNA Damage Signaling Pathways
Background: Chromosome abnormalities are associated with poor morphology and development in human preimplantation embryos, all together lead to poor outcomes. This study aimed to explore altered expression of DNA damage pathways in “poor morphological and development embryos with sever aneuploidies”. Materials and Methods: Surplus day-4 embryos of PGD cases were pooled in two groups: Poor progn...
متن کاملTelomere lengths in human oocytes, cleavage stage embryos and blastocysts
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA repair proteins. Telomeres shorten during each cell division in the absence of telomerase. When telomere length becomes critically short, cell senescence occurs. Telomere length therefore reflects both cellular ageing and capacity for division. We have measured telomere length in human germinal vesicle (GV) oo...
متن کاملTelomere DNA Deficiency Is Associated with Development of Human Embryonic Aneuploidy
Aneuploidy represents the most prevalent form of genetic instability found in human embryos and is the leading genetic cause of miscarriage and developmental delay in newborns. Telomere DNA deficiency is associated with genomic instability in somatic cells and may play a role in development of aneuploidy commonly found in female germ cells and human embryos. To test this hypothesis, we develope...
متن کاملI-35: Genetic Aberrations in Early Development:The Origins and The Fates
Genetic aberrations are commonly seen in human preimplantation embryos. Non-disjunction and premature division of a chromosome are common in both meiosis and mitosis divisions. The expected result for meiotic aneuploidies is full aneuploidy in the later stages whereas mosaicism is the most frequent event in the cleavage and blastocyst stages. The main causes for mosaicism are post-zygotic event...
متن کاملP-125: The Pregnancy Success Rate of IVF/ICSI with and without The Use of PGSin Female Partner over 35 Years Old Referred to Tehran Infertility Centers
Background: Preimplantation genetic aneuploidy screening (PGS) has been performed during the last decade as a way of enhancing embryo selection in patients with an increased incidence of embryonic numerical chromosome abnormalities (advanced maternal age, recurrent miscarriage, and recurrent implantation failure). It has been proposed that the replacement of euploid embryos in these patients wo...
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عنوان ژورنال:
- Reproductive biomedicine online
دوره 28 5 شماره
صفحات -
تاریخ انتشار 2014